HACER is an atlas of Human ACtive Enhancer to interpret Regulatory variants. The purpose of this atlas is to provide cell-specific active human enhancers, which were derived from GRO/PRO-seq and CAGE data. The atlas is a comprehensive resource for enhancer annotation, including expression, supporting by VISTA, ENCODE, Ensembl and ChromHMM, is part of super enhancer or not, upstream binding TFs, downstream targets with experimental chromatin interaction data, eQTL, and GWAS.
Another major purpose of this atlas is to provide tools for interpreting GWAS SNPs or eQTL variants by exploring enhancer functions. By providing SNP of interest, users can get a list of enhancers with searched SNP, and a visualization of TF-Enhancer-Target regulatory network. The annotation of binding sites, targets, GWAS and eQTL for each enhancer can also be seen. By providing Gene of interest, users can get a list of integrated enhancers target on the searched gene or with the eQTL variants which associated with the searched gene. For ecah integrated enhancer, users can get a visualization of TF-Enhancer-Target regulatory network, and annotation of binding sites, GWAS and eQTL for each individual enhancers integrated.
Browse enhancers by selecting cell line(s).
Search enhancers by coordinate, upstream TF or target gene.
Explore enhancer functions by GWAS SNP, eQTL, target gene, or egene (eQTL gene).
Download enhancers by cell line.
Submit feed back.
Report new dataset.
| Cell line: | 265 |
| Tissue: | 42 |
| Enhancer: | 1,676,284 |
| Enhancer supported by VISTA: | 8,789 |
| Enhancer supported by ENCODE: | 1,173,185 |
| Enhancer supported by Ensembl: | 102,909 |
| Enhancer supported by ChromHMM: | 1,244,594 |
| Enhancer included in super enhancer (dbSuper): | 965,752 |
| TF-enhancer binding: | 772,902 |
| Validated enhancer-promoter interaction: | 4,315,781 |
| eQTL: | 1,581,613 |
| GWAS: | 3,435 |