HACER is an atlas of Human ACtive Enhancer to interpret Regulatory variants, which includes active, transcribed enhancers derived from GRO-seq, PRO-seq and CAGE data.
HACER not only contains cell-type-specific enhancers but also connects enhancers into transcriptional regulatory network by integrating TF-enhancer bindings and validated chromation interactions. HACER represents a unique resource for studies on non-coding variants and enhancer-mediated regulation.
All the data in HACER is based on genome hg19.
Browse enhancers by selecting cell line(s).
Query enhancers to interpret GWAS risk SNPs and eQTL variants.
SNP: Search a GWAS risk SNP or eQTL variant to find cell-type-specific enhancers harboring the SNP/variant, and show TF-enhancer-gene interactions.
Gene: Search a gene to find cell-type-specific enhancers targeting this gene.
Coordinate: Search a genomic region to find cell-type-specific enhancers overlapping this region.
Batch: Search a set of genomic regions to obtain an annotation summary on cell-type-specific enhancers, TF-enhancer-target interactions and associated GWAS phenotypes, and to prioritize them based on their annotations.
Download enhancers by cell line.
Submit feed back.
Report new dataset.
| Cell line | 265 |
| Tissue | 42 |
| 1,676,284 | |
| Enhancer supported by VISTA | 8,789 |
| Enhancer supported by ENCODE | 1,173,185 |
| Enhancer supported by Ensembl | 102,909 |
| Enhancer supported by ChromHMM | 1,244,594 |
| Enhancer included in super enhancer (dbSuper) | 965,752 |
| TF-enhancer binding | 772,902 |
| Validated enhancer-promoter interaction | 6,460,619 |
| eQTL | 1,581,613 |
| GWAS | 3,435 |
To cite HACER, please refer to our publication in Nucleic Acids Research: HACER: an atlas of human active enhancers to interpret regulatory variants. (PMID:30247654).