HACER: Human ACtive Enhancer to interpret Regulatory variants
Center for Quantitative Sciences at Vanderbilt University Medical Center

Purpose of HACER

HACER is an atlas of Human ACtive Enhancer to interpret Regulatory variants, which includes active, transcribed enhancers derived from GRO-seq, PRO-seq and CAGE data.

HACER not only contains cell-type-specific enhancers but also connects enhancers into transcriptional regulatory network by integrating TF-enhancer bindings and validated chromation interactions. HACER represents a unique resource for studies on non-coding variants and enhancer-mediated regulation.

What you can do here

All the data in HACER is based on genome hg19.

Browse enhancers by selecting cell line(s).

Query enhancers to interpret GWAS risk SNPs and eQTL variants.

SNP: Search a GWAS risk SNP or eQTL variant to find cell-type-specific enhancers harboring the SNP/variant, and show TF-enhancer-gene interactions.

Gene: Search a gene to find cell-type-specific enhancers targeting this gene.

Coordinate: Search a genomic region to find cell-type-specific enhancers overlapping this region.

Batch: Search a set of genomic regions to obtain an annotation summary on cell-type-specific enhancers, TF-enhancer-target interactions and associated GWAS phenotypes, and to prioritize them based on their annotations.

Download enhancers by cell line.


Submit feed back.

Report new dataset.


Cell line 265
Tissue 42
Enhancer supported by VISTA 8,789
Enhancer supported by ENCODE 1,173,185
Enhancer supported by Ensembl 102,909
Enhancer supported by ChromHMM 1,244,594
Enhancer included in super enhancer (dbSuper) 965,752
TF-enhancer binding 772,902
Validated enhancer-promoter interaction 6,460,619
eQTL 1,581,613
GWAS 3,435

Cite Us

To cite HACER, please refer to our publication in Nucleic Acids Research: HACER: an atlas of human active enhancers to interpret regulatory variants. (PMID:30247654).